3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virusArticle Published on 2022-10-172022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation administration antiviral target cell injury Combination COVID-19 Critical Cytokine storm dependent on drugs facilitate FFA FFAs free fatty acid Host humans IAV Infection influenza A virus inhibitor inhibitors investigated late stage LDs limit Lipid lipid droplet lipolytic lung lung lesion Malnutrition membrane transporter mice mitigate Mortality outbreak pandemic patients pharmacological Proinflammatory cytokine PROTECT reduce Replication replication of SARS-CoV-2 rescued RNA RNA virus SARS-CoV-2 SARS-CoV-2-infected hamsters significantly suppressed therapeutic target Treatment viral infections virus virus-infected cell [DOI] 10.1038/s41392-022-01223-4 PMC 바로가기
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recoveryArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome affected animal model change coronavirus correlated COVID COVID-19 demonstrated detectable exceeded hamster highlight host response Human IAV individual Infection Infectious virus influenza A virus Injury interferon response kidney lack lung mechanism molecular mechanism olfactory Olfactory epithelium PASC pathology Perturbation Proinflammatory cytokine response Result SARS-CoV-2 SARS-COV-2 infection sustained T cell activation tissue transcriptional change unique viral clearance [DOI] 10.1126/scitranslmed.abq3059 PMC 바로가기
Impact of COVID-19 on viral respiratory infection epidemiology in young children: A single-center analysisArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Public Health [Category] SARS, 치료기술, [키워드] Analysis analyzed benefit Bonferroni correction children Concomitant COVID-19 COVID-19 pandemic described epidemiological Epidemiology Fisher Health Hypothesis IAV IBV Impact indicated Infectious disease Influenza influenza A influenza virus Intervention no significant difference Non-pharmaceutical interventions not significantly different NPI NPIs observé occurred Occurrence outpatient clinic pandemic parainfluenza virus 3 pediatric presented later presenting reduce reduction in reported respiratory respiratory infection respiratory infection. respiratory pathogen respiratory syncytial virus RSV SARS-CoV-2 SARS-CoV-2 PCR tests significantly significantly higher significantly lower single-center Spread study period Surveillance tested University Hospitals Leuven viral respiratory infection virus virus were used [DOI] 10.3389/fpubh.2022.931242 PMC 바로가기
Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2 Research Published on 2022-08-182022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Administered administration Antiviral applicability approach conserved Critical disease drugs genetic change Genome greater hamster highlight IAV identify Immunity implication in vitro in vivo influenza A virus isolates mice Mutation nucleic acid predicted Prophylactic Prophylaxis provided retained RNA RNA secondary structure RNA structure SARS-CoV-2 secondary structure survival the SARS-CoV-2 therapeutic targeting therapy Transmission Vaccine variant viral genome Viral RNA virus [DOI] 10.1038/s41591-022-01908-x [Article Type] Research
Co-existence and co-infection of influenza A viruses and coronaviruses: public health challengesReview article Published on 2022-08-172022-10-05 Journal: The Innovation [Category] 비임상, [키워드] acute respiratory syndrome affecting aggravate Alter both virus caused circulation co-existence Co-infection coronavirus CoV CoVs Cross-species transmission disease disease transmission Evolution facilitate FIVE Genetic host range hosts Human IAV influenza A virus influenza A virus maintain Pandemics public health public health challenges Recombination risk SARS-CoV-2 Surveillance variant virus [DOI] 10.1016/j.xinn.2022.100306 [Article Type] Review article
Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents인간 폐 상피 조직 동등물에서 SARS-CoV-2 및 인플루엔자 감염 및 항바이러스 치료 모델링Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] alveolar Analysis antiviral drug Antiviral treatment antiviral treatments Biomarker cell type cell types cellular chemokine class Critical CXCL10 cytokine Cytokine storm develop emerging viruses epithelial exhibiting human lung IAV IFN response IL-10 IL-6 in vitro in vivo include infect Infection infections Influenza influenza A influenza A virus influenza infection MHC MHC class I modeling Pathogens peaking pharmacological platform Replication robust SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 Single-cell RNA sequencing throughput tissue tissues tracheobronchial Validity Viral viral infection virus viruses [DOI] 10.1038/s42003-022-03753-7 PMC 바로가기 [Article Type] Article
A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in MiceVirion 기반 조합 백신은 쥐의 인플루엔자 및 SARS-CoV-2 질병으로부터 보호합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration antigenic antigenic drift approach boost immunity breadth combination vaccine Coronaviruses disease distribution domain elicited generate Genetic IAV immunogenic incorporation independent Influenza influenza A influenza A virus influenza vaccine influenza vaccines influenza vaccines. influenza virus Influenza virus influenza viruses Longevity mice Neutralizing antibodies neutralizing antibody New pandemic Particles pathogen Pathogens platform Protein provided respiratory respiratory virus respiratory viruses robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants Seasonal influenza shown the SARS-CoV-2 vaccination Vaccine vaccine production Vaccines variant virus viruses [DOI] 10.1128/jvi.00689-22 PMC 바로가기 [Article Type] Article
Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions Research Published on 2022-07-132022-10-05 Journal: Nature Communications [Category] 변종, [키워드] assumed binding cell line contribute heterogeneity high affinity host adaptation human receptors IAV in vivo influenza A virus influenza A virus Interaction less non-binding Pandemics pathway provided receptor receptors secreted sialic acid Spanish flu specificity These cells viruses zoonotic [DOI] 10.1038/s41467-022-31840-0 [Article Type] Research
Enrichment analysis on regulatory subspaces: A novel direction for the superior description of cellular responses to SARS-CoV-2규제 부분 공간에 대한 농축 분석: SARS-CoV-2에 대한 세포 반응의 우수한 설명을 위한 새로운 방향Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자, [키워드] affected Algorithm Analysis applied Biclustering Cell cell line cellular response Characteristics classic Clustering Comparative analysis complex Computational biology Coverage COVID-19 database Discriminative regulatory patterns enrichment enrichment analysis False positive functional enrichment Functional enrichment analysis GO term GO terms H1N1 IAV identify Impact IMPROVE in vivo infected cell infected cells Interaction KEGG pathway knowledge knowledge extraction lack lung cell line lung cell lines machine machine learning machine learning algorithm machine learning approach motivation observations pathophysiological performed Predictive Regulatory RSV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus scarcity significantly the SARS-CoV-2 virus transcriptional response transcriptomic data transcriptomics transcriptomics. variant virus viruses [DOI] 10.1016/j.compbiomed.2022.105443 PMC 바로가기 [Article Type] Article